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Finally Herpes controlled Resveratrol

Question:
I was diagnosed with herpes HSV 2 3 years ago. I have tried many natural remidies since then and learnt a lot from this forum. Now I am able to control my infection purely with natual stuff. I thought I owe it to the forum to explain what I am doing and what in my opinion works and what does not.

What did not help me:

1) Lysine
2) coconut monolaurin

What helped:

1) Olive leaf extract (500mg 15% oleuropein) 6 caps a day
2) Purell daily application
3) Decaff green tea extract about 300mg of pure EGCG per day

With the above 3 things I was able to finally control my out breaks. I use to have an out break every two months but with above protocol had only one very mild outbreak in 9 months.

Then I starting taking resveratrol for its longevity benefits and realized that its helping my HSV. Now I have significantly reduced olive leaf extract and green tea(often do not take them for days). Stopped purell altogether. Resveratrol at divided doses totally upto 220mg per day gives me perfect control over my infection. No tingling and no outbreaks. I am happy and would encourage you all to try it too.

In addition i take a good multivitamin and 6-8 grams of vitamin C per day.However, I am not sure if it has had any impact on the control of my HSV 2 infection.

Hope this helps.

Answer:
Here is some scientific backing for my experience:

http://www.medscape.com/medline/abstract/10551373

Resveratrol inhibition of herpes simplex virus replication.


Key journal articles ranked for newsworthiness and clinical relevance in each specialty, linked to Medline abstracts.
Antiviral Res. 1999; 43(3):145-55 (ISSN: 0166-3542)
Docherty JJ; Fu MM; Stiffler BS; Limperos RJ; Pokabla CM; DeLucia AL
Department of Microbiology and Immunology, Northeastern Ohio Universities College of Medicine, Rootstown 44272, USA. jjd@neoucom.edu

Resveratrol, a phytoalexin, was found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent, reversible manner. The observed reduction in virus yield was not caused by the direct inactivation of HSV by resveratrol nor inhibition of virus attachment to the cell. The chemical did, however, target an early event in the virus replication cycle since it was most effective when added within 1 h of cell infection, less effective if addition was delayed until 6 h post-infection and not effective if added 9 h post-infection. Resveratrol was also found to delay the cell cycle at S-G2-M interphase, inhibit reactivation of virus from latently-infected neurons and reduce the amount of ICP-4, a major immediate early viral regulatory protein, that is produced when compared to controls. These results suggest that a critical early event in the viral replication cycle, that has a compensatory cellular counterpart, is being adversely affected.


PreMedline Identifier: 10551373


Here is one more:

http://www.medscape.com/medline/abst...76885?prt=true

Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells.
Antiviral Res. 2006; 72(3):242-51 (ISSN: 0166-3542)
Faith SA ; Sweet TJ ; Bailey E ; Booth T ; Docherty JJ
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA.

Resveratrol inhibits herpes simplex virus (HSV) replication by an unknown mechanism. Previously it was suggested that this inhibition may be mediated through a cellular factor essential for HSV replication [Docherty, J.J., Fu, M.M., Stiffler, B.S., Limperos, R.J., Pokabla, C.M., DeLucia, A.L., 1999. Resveratrol inhibition of herpes simplex virus replication. Antivir. Res. 43, 145-155]. After examining numerous cellular factors, we report that resveratrol suppresses NF-kappaB (NF-kappaB) activation in HSV infected cells. Reports have indicated that HSV activates NF-kappaB during productive infection and this may be an essential aspect of its replication scheme [Patel, A., Hanson, J., McLean, T.I., Olgiate, J., Hilton, M., Miller, W.E., Bachenheimer, S.L., 1998. Herpes simplex type 1 induction of persistent NF-kappa B nuclear translocation increases the efficiency of virus replication. Virology 247, 212-222; Gregory, D., Hargett, D., Holmes, D., Money, E., Bachenheimer, S.L., 2004. Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-RelA/p65 pathway. J. Virol. 78, 13582-13590]. Electromobility shift assays determined that resveratrol, in a dose dependent and reversible manner, suppressed activation of NF-kappaB in Vero cells infected with HSV-1, HSV-2 and acyclovir resistant HSV-1. Furthermore, resveratrol did not protect IkappaBalpha, a cytoplasmic NF-kappaB inhibitor, from degradation in HSV-1 infected cells. Immunohistochemical studies demonstrated that RelA/p65, a component of the dimeric NF-kappaB complex, translocated to the nucleus of HSV-1 infected cells in the presence of resveratrol. Finally, direct effects on viral transcription and DNA synthesis were evaluated. Real-time RT-PCR analysis showed that resveratrol treatment of infected cells resulted in reductions of mRNA for ICP0, ICP4, ICP8 and HSV-1 DNA polymerase by 2.1-, 3.3-, 3.8- and 3.1-fold, respectively. Plus, mRNA for glycoprotein C, an HSV late gene, was completely absent in the presence of resveratrol. Lastly, quantitative PCR showed that resveratrol significantly blocked HSV DNA synthesis. Cumulatively, these data indicate that resveratrol (i) suppresses HSV induced activation of NF-kappaB within the nucleus and (ii) impairs expression of essential immediate-early, early and late HSV genes and synthesis of viral DNA.

PreMedline Identifier: 16876885




Seems resveratrol is also effective when applied topically but I have never needed that as I have not had an outbreak since I am taking resveratrol.

http://www.medscape.com/medline/abst...25258?prt=true
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Effect of resveratrol on herpes simplex virus vaginal infection in the mouse.
Antiviral Res. 2005; 67(3):155-62 (ISSN: 0166-3542)
Docherty JJ ; Fu MM ; Hah JM ; Sweet TJ ; Faith SA ; Booth T
Department of Microbiology/Immunology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA. jjd@neoucom.edu

Resveratrol (3,5,4'-trihydroxystilbene) is a natural component of certain foods, such as grapes, that, when topically applied, has been shown to limit HSV-1 lesion formation in the skin of mice [Antiviral Res. 61:19-26, 2004]. To determine if it is active on genital HSV infection, the vagina of mice were infected with HSV-2 or HSV-1 and treated with a cream formulation of resveratrol. Mice were evaluated daily for extravaginal disease and vaginal swabs were taken regularly and assayed for infectious virus. Initial studies demonstrated that 19% resveratrol cream administered intravaginally five times a day for 5 days beginning 1h after infection significantly reduced HSV-2 replication beginning on day 1 of infection and prevented extravaginal disease when compared to animals treated with placebo. When resveratrol was tested at a concentration of 6.25% and 12.5% administered five times a day, 6.25% limited virus replication only on day 1 and delayed development of extravaginal disease by 1 day. However, 12.5% resveratrol inhibited HSV-2 replication beginning on day 1 and abolished extravaginal disease. If the number of applications per day was reduced to three for 5 days, 12.5% resveratrol inhibited HSV-2 replication only on day 1, while 19% resveratrol inhibited it throughout the 9-day assay period. When the animals with three treatments per day were examined for extravaginal disease, it was found that 12.5% resveratrol was ineffective when compared to placebo, while animals treated with 19% resveratrol did not exhibit extravaginal disease. When treatment was delayed 6h, 12.5% resveratrol did not inhibit HSV-2 replication or extravaginal lesion formation, but 19% resveratrol did. When resveratrol was used to treat vaginal HSV-1 infection, it was found that 12.5% resveratrol did not limit replication or prevent extravaginal lesion formation. In contrast, 19% resveratrol did significantly limit vaginal HSV-1 replication and reduced extravaginal lesion formation, but the latter was not significant. Mortality rates in placebo-treated animals was 37%, 6.25% resveratrol-treated animals was 40%, 12.5% resveratrol-treated animals was 24%, and 19% resveratrol-treated animals was 3%. Collectively, these results demonstrate that resveratrol cream inhibits or reduces HSV replication in the vagina of mice and limits extravaginal disease.

PreMedline Identifier: 16125258


As you can see that I have nothing to gain here, I am not selling any product. Neither I have any interest in any resveratrol manufacturer. I just want to share what has worked for me. The good thing about resveratrol is that potentially you may enjoy a longer life because of it while effectively suppressing your herpes infection. As it stops viral replication it may also potentially reduce viral shedding, though I am not aware of any study which has been done to measure that.

Any thoughts? anyone?

Answer:
where have you bought it?????
with all the hype about grape jucie being equal to wine for heart health--I wonder if this could be helpful too...
????

Answer:
It is nice to see an argument for a potential treatment that one is willing to actually support with publicly available information, vs. the "HERE'S A CURE! TRUST ME!" chorus so often sung here. THANK YOU.

No comments, except readers may have interest in John J. Docherty's profile which I found at http://myprofile.cos.com/docher30. What is important about what you have provided and this profile in my opinion, is not whether there is or is not a potential treatment, but rather that the research/sponsors/researchers/patents etc. can be cross referenced so that people can learn what is valuable on their own. I couldn't find good information on his sponsors (Royalmount) but it does seem that they are at least in a joint effort in some research with the National Cancer Institute, which one could verify on their own. Thanks.

Answer:
Thanks Tohealth, I am just returning what the community gave me in terms of support and ideas.

Hawk I could recommend the brands which I use but I do not think that is important and I also dont want to dilute the force of my message by recommending brands.

I have no profits to make here, I am not a stake holder in any health business.

I would recommend that you do your own search for sources of resveratrol.

I will not respond to PM asking for sources. There are many manufacturers choose any reputable ones. One idea may be to use more than one source and see how you do.

Answer:
Hi Whoknows,


Can you tell us how long you have been taking "resveratrol", and how long since your last outbreak?

Thanks,

Joh

Answer:
been taking it for about 3 weeks now and i so far no outbreaks.....before this i had one for like 2m s8t

Answer:
Joh, I have been taking resveratrol for atleast 6 months now and no outbreaks, previously before i started taking Olive leaf and other things i had almost one outbreak a month.

Others may i please request do not discuss the specific products here. I would prefer to keep this thread clean.

All i would say is the the senstivity of resveratrol to light is over hyped and most of the products on the market are good. So lets not swear by a product. I say this because i have tried many resveratrol products and found them all to be good and working.

I would go for any reputable name.

Answer:
The mice part is kinda creepy I really hate that they use animals for study but I guess it wouldn't be acceptable to purposefully infect humans to do a study. I wonder how a mouse vagina compares to human since our immune systems are different and we are zoologically very different.

I should go and research your info but I just want to know the bottom line. Is this a product made from grape seed extract of some kind? I am assuming the product name is proprietary? How can I know what is in this product?

I see that it is in conjunction to oral antivirals so how do they determine what is causing the viral suppression if they are used together? How long tested? Blind study? How many individuals and only HSV1 or HSV2 also? Long term side effects? Drug interactions?
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